Seven of the most frequent spinocerebellar ataxias (SCAs) are caused by a pathological expansion of a cytosine, adenine and guanine (CAG) trinucleotide repeat located in exonic regions of unrelated genes, which in turn leads to the synthesis of polyglutamine (polyQ) proteins.PolyQ proteins are prone to aggregate and form intracellular inclusions, w
The presence of a rhinolith is a rare condition, which can cause long-standing symptoms, such as rhinorrhea, foul-smelling discharge, nasal obstruction, and headache.A rhinolith is usually easily diagnosed by a clinical examination and a paranasal computed tomographic scan.Rhinoliths are usually found in nasal cavities, but rare mug washer location
Aurora Garre,1 Gemma Martinez-Masana,1 Jaime Piquero-Casals,2 Corinne Granger1 1Innovation and Development, ISDIN S.A., Barcelona, Spain; 2Dermik Clinic, Barcelona, Spain Background: Skin aging is accelerated by multiple extrinsic factors: ultraviolet radiation, smoking and pollution increase oxidative activity, damaging tasoliesi cellular and extr
Rhodiola rosea L.is recognized for its adaptogenic properties and ability to promote muscle health, function and recovery from exercise.The plethora of biological effects of this plant is ascribed to the synergism existing among the molecules composing its phytocomplex.In this manuscript, we analyze the activity of a bioactive fraction extracted fr